Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Kras mutant v WT with or without AZD6244 in vivo study

ABSTRACT: HCT116 (kRas mt) cells and HKH2 (Kras wt) cells were implanted into the right and left flanks of nude mice and either untreated or treated with a MEK inhibitor (AZD6244) over time. Tumours were excised and harvested for RNA extraction at the end of the experiment and hybridised to the Colorectal DSA.

ORGANISM(S): Homo sapiens

SUBMITTER: wendy allen 

PROVIDER: E-MEXP-3557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients.

Guinney Justin J   Ferté Charles C   Dry Jonathan J   McEwen Robert R   Manceau Gilles G   Kao K J KJ   Chang Kai-Ming KM   Bendtsen Claus C   Hudson Kevin K   Huang Erich E   Dougherty Brian B   Ducreux Michel M   Soria Jean-Charles JC   Friend Stephen S   Derry Jonathan J   Laurent-Puig Pierre P  

Clinical cancer research : an official journal of the American Association for Cancer Research 20131029 1

<h4>Purpose</h4>KRAS wild-type status is an imperfect predictor of sensitivity to anti-EGF receptor (EGFR) monoclonal antibodies in colorectal cancer, motivating efforts to identify novel molecular aberrations driving RAS. This study aimed to build a quantitative readout of RAS pathway activity to (i) uncover molecular surrogates of RAS activity specific to colorectal cancer, (ii) improve the prediction of cetuximab response in patients, and (iii) suggest new treatment strategies.<h4>Experimenta  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of human HCT116 parental cells treated with 5-FU or SN38 and non-treated parental cells, 5-FU resistant and SN39 resistant cells
2009-03-30 | E-MEXP-1691 | biostudies-arrayexpress
Transcriptomics Transcription profiling of human 5-FU/VCPT-11 responding and non-responding metastatic colorectal cancer biopsies
2008-12-31 | E-MEXP-1692 | biostudies-arrayexpress
Transcriptomics CRC Primary tumours with Kras status
2012-04-30 | E-MEXP-3549 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of human colorectal carcinoma cell line HCT116 treated with SN38 (7-ethyl-10-hydroxy-20(S)-camptothecin)and sampled at 3 timepoints
2007-11-30 | E-MEXP-1171 | biostudies-arrayexpress
Transcriptomics Pre-treatment metastatic biopsy with response to 5FU and oxaliplatin therapy
2011-10-31 | E-MEXP-3368 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of human colorectal cancer epithelial (HCT116) p53 null cells treated with SN38 for 6, 12 and 24h
2007-11-30 | E-MEXP-1194 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of human myometrial cells transfected by NFKB (p65) and CEBP alone and in combination.
2010-03-24 | E-MEXP-2160 | biostudies-arrayexpress
Transcriptomics Transcription profiling of peripheral blood monocytes from patients with systemic juvenile idiopathic arthritis during active and inactive disease
2007-03-31 | E-MEXP-987 | biostudies-arrayexpress
Transcriptomics Transcription profiling of ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa
2013-01-30 | E-FPMI-1 | biostudies-arrayexpress
Transcriptomics Comparative genomic hybridization of human breast carcinomas
2009-06-01 | E-MEXP-2141 | biostudies-arrayexpress