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Unknown,Transcriptomics,Genomics,Proteomics

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Mushroom body cell type comparison

ABSTRACT: The Drosophila melanogaster mushroom bodies (MBs) are brain structures critical for olfactory memory. The approximately 2000 intrinsic MB neurons are divisible into alpha/beta neurons, alpha'/beta' neurons and gamma neurons by morphology and roles in memory processing. It has also been shown that the different subtypes of MB neurons have different function in the process of memory formation. This difference in function, suggested to us that different types of MB neurons might have different expression profiles. In this study, we used cell-type specific gene expression profiling to gain insight into cellular properties of MB neurons.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Paola Perrat

PROVIDER: E-MEXP-3798 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transposition-driven genomic heterogeneity in the Drosophila brain.

Perrat Paola N PN DasGupta Shamik S DasGupta Shamik S Wang Jie J Theurkauf William W Weng Zhiping Z Rosbash Michael M Waddell Scott S

Science (New York, N.Y.) 20130401 6128

Recent studies in mammals have documented the neural expression and mobility of retrotransposons and have suggested that neural genomes are diverse mosaics. We found that transposition occurs among memory-relevant neurons in the Drosophila brain. Cell type-specific gene expression profiling revealed that transposon expression is more abundant in mushroom body (MB) αβ neurons than in neighboring MB neurons. The Piwi-interacting RNA (piRNA) proteins Aubergine and Argonaute 3, known to suppress tra ...[more]

PMID: 23559253

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