RNAi knock down of VCP in human HeLa cells

ABSTRACT: Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find ~30 transcripts upregulated in a sequence independent manner. Those transcripts encode proteins involved in endoplasmic reticulum stress, apoptosis, and amino acid starvation.

INSTRUMENT(S): GenePix 4000A [Axon Instruments]

ORGANISM(S): Homo sapiens

SUBMITTER: Maga Rowicka 

PROVIDER: E-MEXP-817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress