Dataset Information
Transcription profiling of homozygous Commd1 null mouse embryos to elucidate the underlying mechanism leading to embryonic lethality
Ontology highlight
ABSTRACT:
INSTRUMENT(S): G2565BA DNA microarray scanner [Agilent]
ORGANISM(S): Mus musculus
DISEASE(S): embryonic lethal at day 8.5 to 9.5
SUBMITTER: Bart van de Sluis
PROVIDER: E-MEXP-832 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.
Molecular and cellular biology 20070319 11
COMMD1 (previously known as MURR1) belongs to a novel family of proteins termed the copper metabolism gene MURR1 domain (COMMD) family. The 10 COMMD family members are well conserved between vertebrates, but the functions of most of the COMMD proteins are unknown. We recently established that COMMD1 is associated with the hepatic copper overload disorder copper toxicosis in Bedlington terriers. Recent in vitro studies indicate that COMMD1 has multiple functions, including sodium transport and NF ...[more]
