Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

23 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Microarray analysis of MRC-5 cells infected with Zika virus strains

ABSTRACT: To better understand the critical drivers of Zika virus pathogenicity, we used microarray analysis to evaluate the host responses triggered by Zika virus infection in MRC-5 cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Clement Yau

PROVIDER: E-MTAB-10292 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution

Project description:Manuscript describes the daily dynamics of transcriptional responses in whole blood, from acute to convalescent phase, in severe and non-severe COVID-19 patients.

2020-12-31 | E-MTAB-9721 | biostudies-arrayexpress

Microarray of cell strain-derived induced pluripotent stem cell

Project description:Study of gene expression at passage 1 through 4 following differentiation of stem cells. Study of dengue infected and mock infected gene expression in cells at passage 1 and 4 post differentiation from induced pluripotent stem cells.

2021-05-27 | E-MTAB-10440 | biostudies-arrayexpress

CRISPR screen for the identification of host factors for ZIKA virus infection

Project description:To search for host factors regulating Zika virus infection, we performed a genome-wide loss-of-function CRISPR/Cas9 screen in haploid human ESCs. The regulators were identified by the quantification of enrichment of their mutant clones within a pooled loss-of-function library upon Zika virus infection.

2023-05-31 | E-MTAB-11945 | biostudies-arrayexpress

Transcriptomics in Zika virus-infected human brain organoids

Project description:PolyA+ RNA sequencing of Zika virus-infected human brain organoids at 5 days post-infection.

2017-04-03 | E-MTAB-4811 | biostudies-arrayexpress

Zika virus

Project description:Zika Virus Virus genome sequencing

| PRJNA336379 | ENA

Zika virus

Project description:Zika virus Genome sequencing

| PRJNA344504 | ENA

Zika virus

Project description:Zika virus stock sequences

| PRJNA476611 | ENA

Zika virus

Project description:Zika virus Genome sequencing

| PRJNA315525 | ENA

Genetic analysis of a Zika Virus Envelope Glycosylation and Non-structural protein 4B P36 Double Mutant

Project description:Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Live attenuated vaccines have been successfully used to combat infection by flaviviruses, such as yellow fever and Japanese encephalitis viruses. A Zika virus harboring combined mutations in the envelope protein glycosylation site and in the nonstructural 4B protein amino acid 36 (ZE4B-36) was generated and assessed for stability, attenuation, and protection against infection. To determine the genetic stability of its RNA genome, ZE4B-36 was serially passaged in vitro in Vero cells. Virus harvested from passages (P)1 to P6 was subjected to next generation sequencing and downstream analysis to determine its nucleotide sequence variability. Specifically, single nucleotide variant analysis showed that the ZE4B-36 genome decreased its genetic diversity and resulted in a more stable nucleotide sequence. Thus, in addition to showing attenuation and protection, ZE4B-36 is a stable live attenuated virus that possesses characteristics important for a vaccine to combat Zika disease.

2021-12-31 | E-MTAB-9496 | biostudies-arrayexpress

MiSeq analysis of viral progeny at 24 and 72 hours post-infection with H/PF/2013 Zika virus of HuH-7 cells

Project description:To better understand mutations that can contribute to Zika pathogenesis, we allow the H/PF/2013 wild-type strain to replicate in HuH-7 cells to analyze the population of viral variants.

2021-05-24 | E-MTAB-10474 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data