Whole-blood MicroRNA Sequence Profiling for Adolescents with Postural Tachycardia Syndrome

ABSTRACT: Objective To establish whether whole-blood MicroRNA (miRNA) profiles differ between postural tachycardia syndrome (POTS) sufferers and control subjects, and to identify the miRNA that regulate plasma H2S. Study design: High-throughput sequencing was used to obtain whole-blood miRNA expression profiles for five POTS sufferers and five normal children. miRNAs with an adjusted P-value of <0.05 (by DESeq) and with a log2 fold change ≥3 were considered to be differentially expressed (DEmiRNAs). The target genes of the DEmiRNAs were identified using RNAhybrid and miRanda, and only those identified by both were considered. The combined effects of the DEmiRNAs were determined using KEGG pathway analysis. Another 40 POTS and 20 normal patients were used as validation subjects. Plasma H2S was deter

INSTRUMENT(S): Illumina HiSeq 2000 platform, Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Jing Lin 

PROVIDER: E-MTAB-10961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress