Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - 16S
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina MiSeq
ORGANISM(S): Mus musculus
SUBMITTER: Patricia Brubaker
PROVIDER: E-MTAB-11551 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion.
Martchenko Alexandre A Biancolin Andrew D AD Martchenko Sarah E SE Brubaker Patricia L PL
Scientific reports 20220504 1
The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted by the intestinal L cell in response to nutrient intake. However, GLP-1 secretion also follows a circadian rhythm which is disrupted by the saturated fatty acid palmitate in vitro and high-fat diet (HFD) feeding in vivo. The flavonoid nobiletin is a clock enhancer which improves metabolic homeostasis. Therefore, the aim of this study was to elucidate whether and how nobiletin mitigates the negative effects of palmitate and HFD-feed ...[more]
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