Differentiation-related epigenomic changes define clinically distinct keratinocyte cancer subclasses

ABSTRACT: Keratinocyte cancers (KC) are the most prevalent malignancies in fair-skinned populations, posing a significant medical and economic burden to health systems. KC originate in the epidermis and mainly comprise basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). Here, we combined single-cell transcriptomics, methylomics and multi-omics to investigate the epigenomic dynamics during epidermal differentiation. We identified ~4,000 differentially accessible regions between undifferentiated and differentiated keratinocytes, corresponding to regulatory regions associated with key transcription factors. DNA methylation at these regions defined AK/cSCC subtypes with epidermal stem cell- or keratinocyte-like features. Using cell type deconvolution tools and integration of bulk an

ORGANISM(S): Homo sapiens

SUBMITTER: Llorenç Solé-Boldo 

PROVIDER: E-MTAB-11856 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress