Microarray analysis of peripheral blood mononuclear cells isolated from patients with ANCA-associated vasculitis and healthy controls

ABSTRACT: Patients with anti-MPO vasculitis have increased serum levels of the signalling molecule cGAMP suggestive of ongoing DNA recognition by the cGAS/STING pathway. Consistent with this gene set enrichment analysis of peripheral blood mononuclear cell transcriptomes from patients with active anti-MPO vasculitis revealed up-regulation of type 1 interferon response genes compared to healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Lyons 

PROVIDER: E-MTAB-12008 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress