Transcriptional profiling of PKH26-labeled colorectal cancer stem cells

ABSTRACT: Quiescent cancer cells responsible for tumor chemoresistance and relapse have been identified in several tumors but in colorectal cancer (CRC) they remain largely undefined. By using a proliferation-sensitive dye, we isolated and characterized a rare subpopulation of cells from colorectal tumors which, upon gene expression, proteomic and functional studies, revealed combined features of stemness, drug resistance and epithelial-to-mesenchymal transition (EMT). Altogether, this work reveals a link between cell quiescence, EMT and therapy resistance relevant for targeting drug-resistant populations in CRC.

ORGANISM(S): Homo sapiens

SUBMITTER: Alessandro Bruselles 

PROVIDER: E-MTAB-12041 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress