Glucocorticoid Resistance Gene Profiling in T-ALL Cell Lines

ABSTRACT: Baseline glucocorticoid resistance profiles were measured in a panel of 15 paediatric T-Cell acute lymphoblastic leukaemia cell lines and correlated with Affymetrix Gene expression to identify genes and pathways associated with drug resistance in T-ALL. The cell lines' resistance to Methylprednisolone (MPRED) and Dexamethasone (DEX) was then tested using the MTT assay and IC50 values (drug concentration lethal to 50% of cells) for each drug were calculated.

ORGANISM(S): Homo sapiens

SUBMITTER: Alex Beesley 

PROVIDER: E-MTAB-1208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress