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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Estrogen and xenoestrogen modulated transcriptome in the liver of juvenile female Atlantic cod (Gadus morhua)

ABSTRACT: Estrogens regulate many reproductive processes in fish and other vertebrates. In fish, the pituitary and liver are among the main sites of action of estrogens in the reproductive brain-pituitary-gonadal-hepatic axis. Environmental contaminants with estrogenic compounds acting at these organs have the potential to interfere with the reproductive processes in fish. In this work, RNA-seq analysis was performed to map estrogen and xenoestrogen target genes in the juvenile female Atlantic cod (Gadus morhua) liver after 72 h exposure to estrogenic compounds ethynylestradiol (EE2), and the xenoestrogens bisphenol A (BPA) and methoxychlor (MXC). Our results show that, in the liver, EE2 and the xenoestrogens modulated many genes and pathways related to vitellogenesis and lipid metabolism.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Gadus morhua

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PROVIDER: E-MTAB-12604 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP144932

REPOSITORIES: biostudies-arrayexpress

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