Longitudinal scRNAseq profiling of memory B cells in mRNA vaccinated individuals post BA.1-breakthrough infection

ABSTRACT: Memory B cells play a fundamental role in host defenses against viruses. This dataset aimed at understanding the recruitment and remodeling of the memory B cell repertoire in the context of BA.1-breakthrough infection in BNT162b2 mRNA vaccinated individuals. All four donors enrolled in the study had received a booster (3rd dose) of BNT162b2 mRNA vaccine and had no history of prior SARS-CoV-2 infection. All four experienced a documented breakthrough infection between 12/24/2021 and 01/30/2022 when BA.1 was responsible for > 85% of SARS-CoV-2 infections in France. All donors were sampled at Henri Mondor University Hospital (AP-HP, Paris France), and samples used for scRNA-seq were collected shortly after breakthrough infection (PO_M0 samples; between day 7 and day 18) and 5 to 6 months after

INSTRUMENT(S): 10x Chromium Controller, Illumina NovaSeq 6000, MA900, Sony

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-MTAB-12651 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP145496

REPOSITORIES: biostudies-arrayexpress