Belt electrode-tetanus muscle stimulation prevents denervation-induced atrophy of rat multiple skeletal muscle groups via ribosome biogenesis

ABSTRACT: Belt electrode-skeletal muscle electrical stimulation (B-SES) involves the use of belt-shaped electrodes to simultaneously contract multiple muscle groups. Twitch contractions have been demonstrated to protect against denervation-induced muscle atrophy in rats, possibly via mitochondrial biosynthesis. In this study, we examined whether inducing tetanus contractions with B-SES suppresses muscle atrophy and identified the underlying molecular mechanisms. We evaluated the effects of acute (60 Hz, 5 min) and chronic (60 Hz, 5 min, every alternate day for 1 week) B-SES on the tibialis anterior (TA) and gastrocnemius (GAS) muscles in Sprague Dawley rats using belt electrodes attached to both ankle joints. In acute stimulation, a significant decrease in glycogen content in the left and right TA a

INSTRUMENT(S): Illumina MiniSeq

ORGANISM(S): Rattus norvegicus

SUBMITTER: HiroyukiUHiroyuki Uno 

PROVIDER: E-MTAB-13286 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress