Transcriptomes of subterranean mammals reveal that naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

ABSTRACT: We performed RNAseq, metabolomics and pathway enrichment analysis on cardiac tissue from naked mole-rats (Heterocephalus glaber) and from seven other members of African mole rat genera, Cape mole-rat (Georychus capensis), Cape dune mole-rat (Bathyergus suillus), Common mole-rat (Cryptomys hottentotus hottentotus), Natal mole-rat (C. h. natalenesis), Mahali mole rat (C. h. mahali), Highveld mole-rat (C. h. pretoriae) and Damaraland mole-rats (Fukomys damarensis) representing differing burrow and soil types, degrees of sociality, lifespan and hypoxia tolerance. In addition, we include the evolutionarily highly divergent hottentot golden mole (Ambysomus hottentotus), an Afrotherian subterranean, solitary mammal, and the C57/BL6 laboratory mouse as a standard mammal control. After RNA sequenc

INSTRUMENT(S): N/A, DNBSEQ-G400 FAST

ORGANISM(S): Cryptomys hottentotus hottentotus

SUBMITTER: Chris Faulkes 

PROVIDER: E-MTAB-13808 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress