AAV2-GFP-Calcineurin anchoring disruptor microarray
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Tomasz Boczek
PROVIDER: E-MTAB-14614 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:We have analyzed how interaction of calcineurin with perinuclear signalosome AKAP6 affects the expression profile of transcription factors involved in cAMP/calcium signaling. We have found that calcineurin interacts with AKAP6 in calcium-dependent manner and by using anchoring disruptors, we demonstrated the importance of this interaction for depolarization-induced outgrowth of hippocampal neurons.
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