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Genome-wide occupancies of multiple transcription activators in PDLSCs induced by GIPRA

ABSTRACT: Our previous study (Environ Pollut. 2023;323:121307) has indicated that Glucose-dependent insulinotropic polypeptide receptor (GIPR) is down-regulated in periodontal ligament stem cells (PDLSCs) by cigarette and E-cig. In the current study, ChIP-seq was conducted to study the genome-wide occupancies of phosphorylated CREB (p-CREB), p-STAT, p-ERK and TCF4 in PDLSCs treated with GIPR agonist (GIPRA) (Pro3) GIP (0.5 nM, 24 h, Cat. No. HY-P3584, MCE, China) and ERK1/2 inhibitor SCH772984 (0.5 μM, 24 h, HY-50846, MCE) compared to normal PDLSCs.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Yihang Shen

PROVIDER: E-MTAB-15381 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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