Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome sequencing of PDLSCs induced by GIPR and GLP1R alteration

ABSTRACT: Transcriptome sequencing of PDLSCs induced by GIPR and GLP1R alteration

PROVIDER: PRJEB93789 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptome sequencing of PDLSCs induced by GIPR and GLP1R alteration

Project description:Our previous study (Environ Pollut. 2023;323:121307) has indicated that Glucose-dependent insulinotropic polypeptide receptor (GIPR) and Glucagon-like peptide-1 receptor (GLP1R) are down-regulated in periodontal ligament stem cells (PDLSCs) by cigarette and E-cig. In the current study, we focus on investigating the functional roles of these two G protein-coupled receptors in PDLSCs, as well as their molecular mechanisms behind it. In brief, human PDLSCs treated with GIPR-siRNA, GIPR agonist (GIPRA) as well as GIPR, GLP1R dual agonist (2GRA) were used to study the effects of GIPR on cell growth of PDLSCs. Moreover, PDLSCs were induced to undergo osteogenic, adipogenic, chondrogenic, and neurogenic differentiation in vitro. GLP1R siRNA, GLP1R agonist (GLP1RA), and 2GRA were respectively administered to investigate the effects of GLP1R on the differentiation potential of PDLSCs.

2025-07-25 | E-MTAB-15372 | biostudies-arrayexpress

Transcriptome-wide occupancies of IFIT1 and eIF3C in osteogenic PDLSCs treated with GLP1R knockdown

Project description:We have observed that the expression of IFIT1, IFIT2, IFIT3 and the other genes related interferon are all elevated by GLP1R knockdown whereas reduced by GLP1RA and 2GRA in multiple lineages differentiation systems of PDLSCs. It was reported that IFIT proteins could block the formation of 43S pre-initiation complex and 48S initial complex via interacting with eIF3E and eIF3C. RIP-seq was conducted to study the transcriptome-wide occupancies of IFIT1 and eIF3C in osteogenic PDLSCs treated with GLP1R knockdown compared to regular osteogenesis.

2025-07-06 | E-MTAB-15387 | biostudies-arrayexpress

Genome-wide occupancies of multiple transcription activators in PDLSCs induced by GIPRA

Project description:Our previous study (Environ Pollut. 2023;323:121307) has indicated that Glucose-dependent insulinotropic polypeptide receptor (GIPR) is down-regulated in periodontal ligament stem cells (PDLSCs) by cigarette and E-cig. In the current study, ChIP-seq was conducted to study the genome-wide occupancies of phosphorylated CREB (p-CREB), p-STAT, p-ERK and TCF4 in PDLSCs treated with GIPR agonist (GIPRA) (Pro3) GIP (0.5 nM, 24 h, Cat. No. HY-P3584, MCE, China) and ERK1/2 inhibitor SCH772984 (0.5 μM, 24 h, HY-50846, MCE) compared to normal PDLSCs.

2025-08-06 | E-MTAB-15381 | biostudies-arrayexpress

Transcriptome-wide occupancies of IFIT1 and eIF3C in osteogenic PDLSCs treated with GLP1R knockdown

Project description:Transcriptome-wide occupancies of IFIT1 and eIF3C in osteogenic PDLSCs treated with GLP1R knockdown

| PRJEB94193 | ENA

Single cell RNA sequencing of Gipr- and Glp1r-expressing cells in the mouse hypothalamus

Project description:Single cell RNA sequencing of Gipr- and Glp1r-expressing cells in the mouse hypothalamus

| PRJNA819265 | ENA

The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.

Project description: Not available

| S-EPMC12903609 | biostudies-literature

Comparison of testes gene expression in Gipr–/– and Gipr+/+

Project description:The aim is to compare gene expression profiles of Gipr–/– mice testes with those of Gipr+/+ mice testes.

2016-09-30 | GSE72504 | GEO

Cald1 regulates osteogenic differentiation of PDLSCs.

Project description:To explore underlying mechanisim of which Cald1 regulates osteogenic differentiation of PDLSCs, RNA -seq was performed on PDLSCs treated with NC shRNA and Cald1 shRNA respectively.

2025-06-30 | GSE236009 | GEO

Association of GLP1R and GIPR variants with obesity and related metabolic disorders.

Project description:In this project the researchers wanted to estabslish the association of GLP1R and GIPR single nucleotide variants with obesity and its comorbidities.

2022-07-24 | PRJEB54891 | EVA

RNA sequencing of human periodontal ligament stem cells (PDLSCs) with Illumina HiSeq2000

Project description:To study the molecular mechanisms underlying PDLSC osteogenic differentiation, we developed RNA sequencing with Illumina HiSeq2000 to comprehensively identify RNA expression profiles in normal PDLSCs, osteogenic inductive PDLSCs and mechanical force-induced PDLSCs. Plenty of RNAs were found to be differentially expressed by RNA sequencing. Furthermore, the potential functions of these RNAs were investigated using bioinformatic analysis.

2018-03-09 | GSE106887 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data