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RNA-seq of Clostridioides difficile ΔsigV、Δanti-sigV against wild-type strain control

ABSTRACT: To reveal the effects of deleting the ΔsigV and Δanti-sigV on clindamycin tolerance in Clostridioides difficile, we first constructed knockout mutants of the sigV and anti-sigV genes and then examined the resulting phenotypic changes, with a particular focus on alterations in clindamycin tolerance. To further elucidate the mechanism underlying the observed changes in clindamycin tolerance, we performed transcriptomic data analysis to identify how sigV and anti-sigV regulate clindamycin-related pathways.

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Clostridium difficile 630

SUBMITTER: Wei Hong

PROVIDER: E-MTAB-15780 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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