Evaluation of a chimeric YF-ZIK vaccine candidate in rhesus macaques

ABSTRACT: In this study, we designed and assessed the immunogenicity and protective efficacy of a chimeric live-attenuated vaccine derived from the yellow fever 17D (YF17D) backbone engineered to express ZIKV antigens. We immunized rhesus macaques with two subcutaneous doses, which rapidly induced neutralizing antibodies and balanced Th1/Th2 responses similar to YF17D. Passive serum transfer protected AG129 mice, confirming antibodies as a key correlate of protection. Upon high-dose ZIKV challenge, vaccinated macaques showed no detectable viral RNA or NS1 seroconversion, indicating sterilizing immunity. Systems analyses revealed TNFRSF17, GNAS, and CD207 as biomarkers linked to antibody responses and immune outcomes. Overall, our workflow demonstrates that YF-ZIK is safe, strongly immunogenic, and p

ORGANISM(S): Macaca mulatta

SUBMITTER: Yeranddy Alpizar 

PROVIDER: E-MTAB-15887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress