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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Concurrent jamming and mesenchymal-to-epithelial transitions during airway basal stem cell differentiation

ABSTRACT: During differentiation of human airway basal stem cells, the confluent epithelium undergoes a phase transition from a fluid-like migratory unjammed phase to a solid-like stationary jammed phase. While mechanisms underlying this process, termed the jamming transition, remain poorly understood, here we demonstrate that the jamming transition coincides with the mesenchymal-to-epithelial transition (MET) during epithelial differentiation. Both the jamming transition and MET are delayed in airway basal stem cells cultured from asthmatic donors, a phenotype which can be recapitulated or abrogated through manipulation of TGF-β receptor activation.

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Homo sapiens

SUBMITTER: Siddhant Kalra

PROVIDER: E-MTAB-16209 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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