TopoIIb ChIP-seq in Doxorubicin-treated neonatal rat cardiomyocytes

ABSTRACT: One proposed molecular mechanism of Doxorubicin-induced cardiotoxicity is the induction of double-strand breaks. Topoisomerase IIb (TopoIIb) binding is dependent on DNA damage. We hypothesized to find novel genomic targets of Doxorubicin-induced cardiotoxixity by identifying differential TopoIIb targets after Doxorubin treatment in cardiomyocytes. Therefore, neonatal rat cardiomyocytes (NRVM) were treated with Doxorubin (1µM for 3h).

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daniel Finke 

PROVIDER: E-MTAB-16326 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress