Genetic introgression and transcriptomic plasticity are associated with enhanced Leishmania infantum pathogenicity causing human cutaneous leishmaniasis in Tunisia

ABSTRACT: The protozoan parasite Leishmania infantum exhibits significant genetic variability among isolates, influencing disease manifestation and treatment response. Although L. infantum is classically described as the causative agent of Visceral Leishmaniasis (VL) – often associated with immune deficiency, cases of Cutaneous Leishmaniasis (CL) caused by this species in immunocompetent individuals have been reported in different countries. With the aim to gain new insight underlying this unusual change in L. infantum tropism and pathogenicity, we applied comparative genomic and transcriptomic approaches on two canine isolates (Lcan) and two human isolates associated with CL in Tunisia. Using DNA-seq analysis, we assessed aneuploidy, gene copy number variations (CNVs), and single-nucleotide polymor

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Leishmania infantum

SUBMITTER: Juliana Pipoli da Fonseca 

PROVIDER: E-MTAB-16364 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress