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Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells

ABSTRACT: Single-cell RNA sequencing revealed a dysregulated myeloid immune response with hyperinflammatory and immunosuppressive features in patients with ASCVD and moderate COVID-19. Assay for Transposase-Accessible Chromatin sequencing and in-vitro experiments with isolated monocytes infected with SARS-CoV-2 showed epigenetic priming of monocytes from patients with ASCVD towards increased expression of inflammatory mediators and type I interferon signalling. In a German nationwide cohort (NAPKON), using multiplex cytokine assays, enzyme-linked immunosorbent assays, and bulk-RNA-sequencing, we confirmed that patients with ASCVD display an exaggerated inflammatory response during moderate COVID-19.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: David John 

PROVIDER: E-MTAB-16472 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells.

Leberzammer Julian J   Abplanalp Wesley Tyler WT   Grikscheit Katharina K   Solomonidis Emmanouil G EG   Glaser Simone-Franziska SF   Schuhmacher Bianca B   Merten Maximilian M   Jeremijev Gligorije G   Wilken-Schmitz Annett A   Korth Lara L   John David D   Günther Stefan S   Kuenne Carsten C   Looso Mario M   Valasarajan Chanil C   Benes Vladimir V   Jung Ferris F   Niehaus Vivianne V   Anton Gabriele G   Stellbrink Christoph C   Römmele Christoph C   Göpel Siri S   Pullamsetti Soni Savai SS   Vehreschild Janne J   Vehreschild Maria M   Ciesek Sandra S   Leistner David M DM   Zeiher Andreas M AM   Dimmeler Stefanie S   Cremer Sebastian S  

Cardiovascular research 20260201 1

<h4>Aims</h4>Patients with cardiovascular disease (CVD) have an increased risk of developing severe respiratory infections, including COVID-19. However, the underlying molecular mechanisms are not completely understood. It has been previously shown that CVD predisposes to an altered responsiveness to subsequent inflammatory triggers by an imprinted epigenetic memory in innate immune cells. Therefore, we hypothesized that patients with pre-existing atherosclerotic cardiovascular disease (ASCVD) a  ...[more]

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