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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Bulk RNA-seq of Peripheral Blood Mononuclear Cells from AmaXhosa Children with Atopic Dermatitis and Healthy Controls in Rural and Urban South Africa

ABSTRACT: This RNA-seq experiment profiles peripheral blood mononuclear cells from AmaXhosa children aged 12–36 months with clinically diagnosed moderate-to-severe atopic dermatitis and matched healthy controls living in rural or urban South African settings. The main goal is to capture systemic immune transcriptional programs associated with early-life atopic dermatitis while accounting for the strong contextual influence of environment. By comparing disease status across rural/urban strata, the dataset is designed to distinguish disease-linked expression patterns from location-associated immune signatures, and to identify gene sets reflecting pathways plausibly involved in atopic inflammation, barrier/immune regulation, and related mechanisms. The resulting transcriptomic signatures are intended for downstream integration with cytokine and antibody measurements and environmental exposure data to support mechanistic interpretation and endotype definition.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Katja Baerenfaller

PROVIDER: E-MTAB-16535 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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