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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic dissection of host-parasite interactions reveals metabolic rewiring in hepatocytes infected with Plasmodium berghei GAPs

ABSTRACT: we perform RNA sequencing to characterize host and parasite transcriptomic changes in hepatocytes infected with Plasmodium berghei GAPs lacking either Stearoyl-CoA Desaturase (Scd) or Sporozoite Conserved Orthologous Transcript 1 (Scot1). Both knockouts elicit distinct host transcriptional responses, prominently affecting genes involved in cytoskeletal organization, cell adhesion, signaling, and lysosomal function. Scot1-deficient parasites exhibit reduced or no expression of Scd, indicating a possible regulatory link.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Plasmodium berghei

SUBMITTER: Dr. Satish Mishra

PROVIDER: E-MTAB-16953 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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