Endothelial C/EBPβ/AEP Pathway Drives Vascular Deterioration and Systemic Aging

ABSTRACT: Age-related microvascular dysfunction disrupts nutrient homeostasis and waste clearance, leading to organ failure. However, a critical gap remains in our understanding of the specific molecular drivers of vascular deterioration and how they orchestrate organism-wide aging. Here, we identify progressive activation of the CCAAT/enhancer-binding protein β (C/EBPβ)/asparagine endopeptidase (AEP) pathway in aging vascular endothelial cells contributes to vascular degeneration and lifespan reduction. Endothelial-specific C/EBPβ or AEP overexpression accelerated vascular aging and shortened lifespan in mice. Mechanistically, AEP mediates proteolytic cleavage of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (oxidised form, NAD+) biosy

INSTRUMENT(S): 10X Chromium Controller, Illumina NovaSeq X

ORGANISM(S): Mus musculus

SUBMITTER: Bowei Li 

PROVIDER: E-MTAB-17006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress