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A cold-induced GDF15-secreting adipocyte subpopulation regulates energy homeostasis through endocrine signaling

ABSTRACT: Brown adipose tissue (BAT) regulates whole-body energy balance through UCP1-dependent thermogenesis and secretion of metabolic factors. Our single-nucleus RNA sequencing of BAT from cold-exposed Ucp1 knockout mice reveals a distinct brown adipocyte subpopulation (U2). U2 adipocytes exhibit a secretory profile enriched in batokines like growth differentiation factor 15 (GDF15), suggesting a shift towards an endocrine role. Functional analyses reveal that GDF15-GFRAL signaling is required to sustain energy expenditure in adipose tissue (AT). Additionally, a conserved UCP1-GDF15 regulatory axis in human AT is observed.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Tongtong Wang

PROVIDER: E-MTAB-17074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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