Transcriptomic profiling of Guanxin Shuxin powder effects on a mouse model of coronary microvascular dysfunction

ABSTRACT: Biological Relevance and Intent Coronary microvascular dysfunction (CMD) is a major driver of myocardial ischemia, yet therapeutic options remain limited. This study aims to evaluate the cardioprotective efficacy of Guanxin Shuxin powder (GXSX), a traditional Chinese medicine, and to elucidate its underlying molecular mechanisms. The research specifically investigates how GXSX modulates metabolic pathways and preserves mitochondrial ultrastructure to improve coronary microvascular perfusion and cardiac function. Experimental Workflow The experimental approach integrated physiological assessment, histopathology, and high-throughput sequencing: In Vivo Model: A mouse model of CMD was established and treated with GXSX. Phenotypic Validation: Cardiac function was monitored via echocardiography

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Shuai Li 

PROVIDER: E-MTAB-17126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress