Dataset Information

Impact of Diabetes and CKD Comorbidity on Cardiac Mitochondrial function, Oxidative Stress, and Structural Remodeling

ABSTRACT: Both diabetes and chronic kidney disease (CKD) predispose individuals to cardiac remodeling and coronary microvascular dysfunction. Our previous studies in swine models have revealed significant alterations in microvascular and myocardial structure and function, along with increased oxidative stress. In the present study, we aim to delineate the effects of diabetes alone and to investigate the combined impact of diabetes and CKD on cardiac performance.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

SUBMITTER: Jan Bernd Stöckl

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD065331 | Pride | 2026-01-23

REPOSITORIES: Pride

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Publications

From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD.

Sen Payel P Sittig Theresa T Hamers Jules J d'Ambrosio Laura L Ornek Irem I Zhang Junqing J Shashikadze Bachuki B Stöckl Jan B JB Bachter Marie M Bierschenk Susanne S Renner Simone S Wolf Eckhard E Clauss Sebastian S Fröhlich Thomas T Nickel Alexander G AG Maack Christoph C Merkus Daphne D

Basic research in cardiology 20251219 1

Both diabetes mellitus (DM) and chronic kidney disease (CKD) predispose to cardiac remodeling and coronary microvascular dysfunction, which is proposed to be mediated through increased oxidative stress. To link oxidative stress and cardiac remodeling in DM and CKD, CKD was induced in genetically modified DM swine (INS<sup>C94Y</sup> transgenic) at 10-12 weeks of age via renal microembolization, while non-embolized DM and wild-type (WT) swine served as controls. Compared to WT, 1) DM animals disp ...[more]

PMID: 41419687

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Dataset Information

Impact of Diabetes and CKD Comorbidity on Cardiac Mitochondrial function, Oxidative Stress, and Structural Remodeling

Dataset's files

Publications

From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD.

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