Concurrent low-dose-rate gamma irradiation and inorganic arsenite in mice: genotoxicity and transcriptional responses in liver and testis in CBA and C57BL/6 mice

ABSTRACT: Mouse testis and liver samples collected one day post-radiation/As-exposure liver and testis genome-wide transcriptional profiles in male mice of two strains (CBA/CaOlaHsd and C57BL/6NHsd) exposed chronically to a low dose rate (2.5 mGy/h; 1200h, LDR), mid-dose rate (10 mGy/h; 300h, MDR), acutely to a high dose rate (100 mGy/h; 30h, HDR) of gamma irradiation – all at total dose 3Gy, Co-60 source. Two additional groups were exposed acutely to 3Gy Xray with and without priming with LDR (i.e., 2 groups, X and LDR_X). Four additional groups were exposed to sodium arsenite (0.3 and 3 mg/L in drinking water, LAs and HAs, respectively), either arsenate alone (LAs, HAs) or combined with LDR gamma (Lg-LAs, Lg_HAs). 5 mice/group/strain standard, except 1 group of 3, 2 groups of 4. ONLY THE raw data for low dose rate gamma and arsenite exposed groups are currently uploaded. The analysis/publication of the testis data for the remaining groups is not yet finished, if ever. The liver raw data for the remaining groups have been deposited at PRJNA747753 (SVA),

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Dag Marcus Eide 

PROVIDER: E-MTAB-17355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress