Clonal heterogeneity in melanoma

ABSTRACT: Genetic heterogeneity is an important feature of solid tumors, however it is often assumed that most cancer cell lines are genetically homogeneous. A disparity in genetic complexity between cell lines and the disease they model could result in problems such as in vitro preclinical experiments overstating the effectiveness of putative therapeutics. We therefore derived clonal sublines by single cell cloning of in house derived early passage melanoma cell lines (LM-MEL-series), and compared their genomes to each other and the parental cell line using Illumina 610-Quad SNP arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Anaka 

PROVIDER: E-MTAB-1753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress