The smooth muscle titin filament system regulates uterus contractility and implantation.
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ABSTRACT: We investigated the impact of smooth-muscle–specific deletion of titin M-band exons 1–2. Understanding how disruption of titin M-band signaling alters uterine smooth-muscle physiology provides insight into the molecular mechanisms controlling coordinated uterine peristalsis, embryo positioning, and implantation. Uterine tissue was collected from E3.5 pregnant conditional titin M-band–deficient and control mice, and RNA was isolated for gene expression profiling using Illumina MouseRef-8 v2.0 Expression BeadChips. Expression data were quantile normalized in GenomeStudio and used for comparative transcriptomic analysis.
ORGANISM(S): Mus musculus
SUBMITTER: Juhi V Sur
PROVIDER: E-MTAB-17587 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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