Transcriptome study of sleep deprivation-induced ischemic tolerance in rats

ABSTRACT: Sleep deprivation (SD) performed before stroke induces an ischemic tolerance state as observed in other forms of preconditioning. As the mechanisms underlying this effect are not well understood we used DNA oligonucleotide microarray analysis, to identify the genes and the gene-pathways underlying SD preconditioning. Gene expression was analyzed 3 days after stroke surgery in four experimental groups: i) SD performed before focal cerebral ischemia induction; ii) SD performed before Sham surgery; iii) IS without SD; and iv) Sham surgery without SD. SD was performed by gentle handling during the last 6h of the light period and ischemia was induced immediately after. Stroke induced a massive alteration in gene expression both in sleep deprived and non-sleep deprived animals. However, compare

ORGANISM(S): Rattus norvegicus

SUBMITTER: Francesca Baracchi 

PROVIDER: E-MTAB-3148 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress