Transcription profiling of CD8 T-cells predicts disease course in Crohn's disease and ulcerative colitis

ABSTRACT: The natural history of Crohn's disease (CD) and ulcerative colitis (UC) is variable. In patients with frequently-relapsing/steroid-refractory disease, sustained remission is more likely if immunomodulators are introduced earlier. However, many patients experience quiescent disease without immunomodulators, and should not be unnecessarily immunosuppressed. Previous attempts to stratify treatment from diagnosis have failed because disease course cannot be reliably predicted. We performed whole genome expression analysis of peripheral CD8 and CD4 T-cells isolated from patients with active, untreated CD or UC. Patients were prospectively managed by clinicians blinded to the microarray results. Analysis of CD8 T-cell gene-expression data revealed two distinct subgroups within each disease cohor

ORGANISM(S): Homo sapiens

DISEASE(S): Ulcerative colitis

SUBMITTER: Tim Rayner 

PROVIDER: E-MTAB-331 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress