Differences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media

ABSTRACT: Study question: Is gene expression in human preimplantation embryos affected by medium used for culturing embryos during an IVF treatment? Summary answer: Six days of in vitro culture of human preimplantation embryos resulted in a medium-dependent expression level of genes involved in apoptosis, protein degradation, metabolism and cell cycle regulation. What is known already: Several human studies have shown an effect of culture medium on embryo development, pregnancy outcome and birthweight. However, the underlying mechanisms in human embryos are still unknown. In animal blastocysts, it has been demonstrated that culture of preimplantation embryos affects gene expression. In humans, it has been found that culture medium affects gene expression of cryopreserved embryos that, after thawin

ORGANISM(S): Homo sapiens

SUBMITTER: Lars Eijssen 

PROVIDER: E-MTAB-3405 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress