Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ

ABSTRACT: The tooth is derived from both the ectoderm and the neural crest (ectomesenchyme). It is often used as a model for studies of the basic mechanisms of organ development, including differentiation, cellular interaction, morphogenesis, and mineralization of extracellular matrices. In mouse, tooth development begins at embryonic day 11.5 (E11.5) by thickening of the dental epithelium, whereas mineralization of enamel and dentin in first molars starts at postnatal day 0 (P0). Tooth development entails a multistep and complex process of gene expression. Studies with genetically modified mice have contributed substantially to our understanding of genes that regulate tooth development and morphology. MicroRNAs (miRNA) are a class of non-coding RNAs that regulate gene expression at a post-transcrip

ORGANISM(S): Mus musculus

SUBMITTER: Amer Sehic 

PROVIDER: E-MTAB-357 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress