Proteomics

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MiR-214-3p inhibits SiO₂-induced macrophage inflammation and attenuates pulmonary fibrosis by targeting Bim in silicosis


ABSTRACT: Silicosis is a devastating occupational lung disease characterized by chronic inflammation and diffuse interstitial fibrosis. Previous studies have shown that miRNA imbalance contributes to silicosis progression, however, the role of miR-214-3p in silicosis is largely unknown. In this study, we performed proteomics analysis of macrophage transfected with miR-NC or miR-214-3p after silica dust exposure for 36 hours, to analyze the effect of miR-214-3p overexpression on SiO2-induced macrophage inflammation.

ORGANISM(S): Mus Musculus

SUBMITTER: Yongbin Hu  

PROVIDER: PXD064802 | iProX | Tue Jun 10 00:00:00 BST 2025

REPOSITORIES: iProX

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