Comparative analysis of transcripts from mia40-4int mutant and wild-type Saccharomyces cerevisiae strains quantified in RNA-seq experiment

ABSTRACT: The vast majority of the mitochondrial proteome originates from nuclear genes and is transported into the organelle after synthesis in the cytosol. Complex machineries, which maintain the specificity of protein import and sorting exist. Dysfunctions of mitochondrial protein sorting pathways result in diminishing specific substrate proteins, followed by systemic pathology of the organelle and organismal death. Cellular responses that are caused by slowdown in the transport of mitochondrial proteins are unknown. Here we have used RNA-seq transcription profiling of Saccharomyces cerevisiae to uncover the changes in the cellular transcriptome in the response to mitochondrial protein import dysfunction caused by mutation in the MIA40 gene. Mia40 is a key component of the mitochondrial intermemb

INSTRUMENT(S): MagNA Lyser, Ion Torrent Proton

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Piotr Bragoszewski 

PROVIDER: E-MTAB-3588 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress