Leukemogenic MLL-ENL fusions induce alternative chromatin states to drive a functionally dichotomous group of target genes

ABSTRACT: MLL fusions are leukemogenic transcription factors that enhance transcriptional elongation through modification of chromatin and RNAPolII. Global transcription rates and chromatin changes accompanying the transformation process were monitored by nascent-RNA-seq and ChIP-seq identifying 165 targets separated into two distinct clades. ChIP-seq data complementing this RNA-seq data set can be found in ArrayExpress under accession number E-MTAB-3593 (http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-3593)

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Robert Slany 

PROVIDER: E-MTAB-3591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress