Lung gene expression of ApoE-/- mice in an 8-month inhalation study to assess exposure effects for a candidate modified risk tobacco product, THS 2.2 compared with conventional cigarettes

ABSTRACT: Cigarette smoking is a major risk factor for the development and progression of diseases such as cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD). Modified risk tobacco products (MRTP) are designed to reduce smoking-related health risks. Suitable animal models are important for understanding smoke-induced pathogenesis. Over an 8-month period, hallmarks of both COPD and CVD were investigated in ApoE?/? mice exposed to conventional cigarette smoke (CS) or to an aerosol from a candidate MRTP, the tobacco heating system (THS2.2). In addition to chronic exposure, cessation or switching to THS2.2 after 2 months of CS were investigated.ﾠ In a systems toxicology approach, classical end points (e.g., physiology, histology) were complemented with transcriptomics, lipidom

ORGANISM(S): Mus musculus

SUBMITTER: Vincenzo Belcastro 

PROVIDER: E-MTAB-3681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress