Downregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.

ABSTRACT: The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, a quantitative trait locus (QTL) influencing blood pressure, left ventricular mass and heart interstitial fibrosis was genetically isolated within 788 kb on chromosome 8 segment of SHR-PD5 congenic strain that contains only 7 genes, including mutant Plzf (promyelocytic leukemia zinc finger) gene. To identify Plzf as a quantitative trait gene, we targeted Plzf in the SHR using the TALEN technique and obtained SHR line harboring mutant Plzf gene with a premature stop codon at position of amino acid 58. The Plzf mutant allele is semi-lethal since approximately 95% of newborn homozygous an

ORGANISM(S): Rattus norvegicus

SUBMITTER: Vladimir Landa 

PROVIDER: E-MTAB-3831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress