Salsalate ameliorates metabolic disturbances by reducing inflammation and oxidative stress and by activating brown adipose tissue in spontaneously hypertensive rats

ABSTRACT: Metabolic syndrome is associated with chronic low-grade inflammation which plays an important role in the pathogenesis of insulin resistance. Salsalate is a non-steroidal anti-inflammatory drug that reduces levels of inflammatory mediators. In the current study, we tested the effects of salsalate on inflammation, oxidative stress and metabolic disturbances in an animal model of inflammation and metabolic syndrome, using spontaneously hypertensive rats that transgenically express human C-reactive protein (SHR-CRP). We treated 15-month-old male transgenic SHR-CRP rats with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP rats were fed a standard diet without salsalate. In a similar fashion, we studied a

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jan Silhavy 

PROVIDER: E-MTAB-5079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress