Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion

ABSTRACT: Autophagy is a lysosomal degradation process involved in the turnover of organelles or other cell constituents, in providing sources for energy production under starving conditions, and in cell metabolism. A key protein in the macroautophagic machinery is the autophagy related protein (Atg) 7. Constitutive deletion of Atg7 is lethal at birth. A conditional deletion of Atg7 in hepatocytes leads to hepatomegaly and in aged animals to liver tumors. With this study, we aimed at analyzing the hepatomegaly development more detailed. The 3- to 4-fold enlargement of the liver takes place between day 25 and 35 after birth (P25-P35) and persists at least until P90. This is accompanied by a change in the expression of enzymes involved in the glycogen/glucose metabolism. While glycogen synthesis is in

ORGANISM(S): Mus musculus

SUBMITTER: Chrysanti Skevaki 

PROVIDER: E-MTAB-4389 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress