Autoantigen microarrays of NZM2328 lupus mice treated with induced CD4+ regulatory T cells or natural CD4+ regulatory T cells

ABSTRACT: Foxp3+ regulatory T cells (Treg), playing a crucial role in the maintenance of immune tolerance and prevention of autoimmune diseases, consist of thymus-derived naturally-occurring CD4+Foxp3+ Treg cells (nTreg) and another CD4+Foxp3+ Treg cells that can be induced ex vivo with TGF-β (iTreg). Although both Treg subsets share similar phenotypes and functional characteristics, they also have potential biologic differences on their biology. However, the role of iTreg in regulating B cells of lupus disease mice remains unclear so far. The lupus-prone New Zealand Mixed 2328 (NZM2328) mouse, a recombinant inbred strain that originated from the crosses among New Zealand Black and New Zealand White mice and their progenies also develops Lupus Glomerulonephritis. NZM2328 mice develop autoantibodies

ORGANISM(S): Mus musculus

SUBMITTER: Weiqian Chen 

PROVIDER: E-MTAB-4441 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress