Gene expression profile of Huh7 cells upon knock-down of FOXA2 or FOXA2-DS-S

ABSTRACT: We used siRNAs to knock-down the gene FOXA2 and the positionally-conserved ncRNA (pcRNA) FOXA2-DS-S is Huh7. We have shown that FOXA2 regulates its own expression by binding its promoter, but it can also affect the expression of the associated pcRNA FOXA2-DS-S. At the same time, we have shown that FOXA2-DS-S is necessary for the expression of the FOXA2 gene. These data suggest that the pcRNA acts locally, in cis, to regulate the expression of FOXA2. With this microarray experiment with aimed to explore further the genome-wide transcriptional effects of FOXA2-DS-S or FOXA2 knock-down.

ORGANISM(S): Homo sapiens

SUBMITTER: Tommaso Leonardi 

PROVIDER: E-MTAB-4517 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress