T cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.

ABSTRACT: It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell lineages and their interactions are being sought. To this end, we studied a mouse model of human T cell acute lymphoblastic leukaemia (T-ALL) and used intravital microscopy to monitor the progression of disease within the bone marrow at both the tissue-wide and single cell level over time. We observed highly dynamic cellular interactions and promiscuous distribution of leukaemia cells that migrated across, and proliferated within multiple bone marrow sub-compartments. Unexpectedly, this environment-

ORGANISM(S): Homo sapiens

SUBMITTER: Mark Robinson 

PROVIDER: E-MTAB-4889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress