Unknown,Transcriptomics,Genomics,Proteomics

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Development of a small molecule for treatment of castration resistant prostate cancer via androgen receptor and IL6/STAT3 pathways

ABSTRACT: A small molecule compound, here called 154, has a dual inhibitor effect of IL6/STAT3 and AR pathway, which reduces AR and STAT3 transcriptional activity in LNCaP cells. To profile the effected genes by compound 154 prostate LNCaP cells were treated with DMSO and compound 154 at 1 uM and 0.4 uM in duplicates in 6-well plate, cells were harvested at 24 hours. All the cells were harvested and total RNA was extracted using Qiazol method followed by Agilent DNA microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Anne Margrete Oyan

PROVIDER: E-MTAB-5102 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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