Dataset Information


DNA methylation profiling of intestinal epithelial cells from paediatric biopsies including Inflammatory Bowel disease and healthy controls

ABSTRACT: We purified the intestinal epithelial cells from biopsies taken from the ileum and colon of a paediatric cohort of IBD patients and healthy controls

ORGANISM(S): Homo sapiens

SUBMITTER: Kate Howell 

PROVIDER: E-MTAB-5463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

Howell Kate Joanne KJ   Kraiczy Judith J   Nayak Komal M KM   Gasparetto Marco M   Ross Alexander A   Lee Claire C   Mak Tim N TN   Koo Bon-Kyoung BK   Kumar Nitin N   Lawley Trevor T   Sinha Anupam A   Rosenstiel Philip P   Heuschkel Robert R   Stegle Oliver O   Zilbauer Matthias M  

Gastroenterology 20171012 3

<h4>Background & aims</h4>We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis.<h4>Methods</h4>We obtained mucosal biopsies (N = 236) collected from terminal ileum and ascending and sigmoid colons of children (median age 13 years) newly diagnosed with IBD (43 with Crohn's disease [CD], 23 with ulcerative colitis [UC]), and 30 children without IBD (co  ...[more]

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