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Genes induced by HERV-K virus retroviral envelop

ABSTRACT: The HERV-K(HML2) family is a group of elements of retroviral origin that are present in the human genome. They are silenced in most normal tissues, but are induced in a number of human cancers. In order to assess the relevance of their expression in these pathologies, the consequences of ectopic expression of the HERV-K(HML2) envelope protein were analysed in human 293T cells. The cells were transfected with a control vector, or an expression vector for the HERV-K(HML2) envelope protein. Total RNA was extracted 24h and 48h post transfection, and duplicate samples were analysed on whole genome transcriptional microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Cecile LEMAITRE

PROVIDER: E-MTAB-5509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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